Systems-Genetics.org

Systems genetics resource for the associations between SNP, gene, pathway (module) and phenotype.

BXD methods

Integrated systems genetics toolkit to probe gene function using multi-omics datasets from BXD mouse cohort. See more details about these methods from the Cell Systems paper, and the background of the BXD mouse cohort from here, here and here.

GeneBridge

GeneBridge predicts gene function and module connections using large-scale multi-species expression compendia. See more details about GeneBridge from the Genome Research paper.

BXD bile acid study

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis See more details about this study in the Cell Metabolism paper.

ITP longevity study

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population See more details about this study in the Science paper.

C. elegans RIAIL longevity study

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan. See more details about this study in the preprint

Studies in CC founder strains

Metabolic study (HFD and CD)

Genetic background and sex control the outcome of high-fat diet feeding in mice See more details about this study in the iScience paper.

AKI-CKD (Folic acid nephropathy)

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population See more details about this study in the JCI Insight paper.

NAFLD-NASH (Western diet and thermoneutrality)

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression See more details about this study in the Journal of Experimental Medicine paper.